Article
Signal transduction defects in growth hormone insensitivity.
Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Feb 1999
Clayton P E, Freeth J S, Whatmore A J, Ayling R M, Norman M R, Silva C M
Abstract excerpt
Growth hormone (GH) insensitivity is a heterogeneous condition that can result from mutations within the GH receptor (GHR) and that can be inherited as both an autosomal recessive and a dominant trait. However, evidence from a small number of growth hormone binding protein (GHBP)-positive families indicates that their GH insensitivity is independent of GHR mutations. Two of these families appear to have distinct...
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