Article
Growth hormone insensitivity: pathophysiology, diagnosis, clinical variation and future perspectives.
Hormone research - 1 Jan 2001
Savage M O, Burren C P, Blair J C, Woods K A, Metherell L, Clark A J, Camacho-Hübner C
Abstract excerpt
The study of genetic growth hormone (GH) insensitivity is an evolving field. GH insensitivity syndrome (GHIS), otherwise known as Laron syndrome, is a heterogeneous disorder. Biochemical features consist of severe insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) deficiency and elevated GH secretion. In a heterogeneous 'European' cohort of GHIS patients, features varied from classical to...
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