Article
[New molecular mechanisms of growth hormone insensitivity].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie - 1 Feb 2008
Edouard T, Raynal P, Yart A, Conte-Auriol F, Salles J-P, Tauber M
Abstract excerpt
Growth hormone (GH), secreted by the anterior pituitary into the circulation, binds to membrane receptors in target tissues to stimulate body growth; most of its effects is mediated by the insulin-like growth factor 1 (IGF-1). In addition to promoting growth, GH has important metabolic actions. The syndrome of GH insensitivity (GHI) was first identified in 1966 by Laron et al. in three children with clinical...
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