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Article

Genetic defects of the growth-hormone-IGF axis associated with growth hormone insensitivity.

Endocrine development - 1 Jan 2007

Woods Katie

Abstract excerpt

The central feature of growth hormone (GH) insensitivity is deficiency of insulin-like growth factor-1 (IGF-1) in association with elevated GH secretion. This condition is also known as primary IGF deficiency. There are currently four known genetic causes of GH insensitivity/primary IGF deficiency: GH receptor deficiency (also known as Laron syndrome or GH insensitivity syndrome), IGF-1 deficiency, signal...

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Identifiers

PMID: 17986822
DOI: 10.1159/000111053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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