Article
Growth hormone insensitivity syndromes: lessons learned and opportunities missed.
Hormone research - 1 Jan 2001
Rosenfeld R G, Buckway C K
Abstract excerpt
The concept of growth hormone (GH) insensitivity has evolved since the condition was originally identified in 1966, and we now know that the primary defect involved is in the GH receptor. Cloning of the receptor molecule has led to great progress in our understanding of GH insensitivity (GHI) and its therapy, including the roles of GH and insulin-like growth factor I (IGF-I) in growth and development, and the...
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