Article
Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma.
Pathology, research and practice - 1 Jan 2004
Park Hye-Rim, Jung Woon Won, Bertoni Franco, Bacchini Patrizia, Park Jae Hoon, Kim Youn-Wha, Park Yong-Koo
Abstract excerpt
Low-grade central osteosarcoma is an uncommon form that is characterized by a long premorbid history, and is compatible with prolonged survival after treatment. However, molecular abnormalities are rare in low-grade central osteosarcomas, whereas p53 mutations occur in approximately 20% of conventional high-grade osteosarcomas. In this study, 21 cases of low-grade central osteosarcoma were analyzed for mutations...
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