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Article

Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status.

Human pathology - 1 May 2017

Yamashita Kyoko, Kohashi Kenichi, Yamada Yuichi, Nishida Yoshihiro, Urakawa Hiroshi, Oda Yoshinao, Toyokuni Shinya

Abstract excerpt

Extraskeletal osteosarcoma (ESOS) is an uncommon malignant neoplasm. Most ESOSs are high grade, although some low-grade cases have been reported. A few cases of ESOS with MDM2 amplification have also been reported, suggesting some similarity to skeletal low-grade osteosarcoma such as parosteal osteosarcoma, where MDM2 is often amplified. However, the frequency of low-grade cases and cases with MDM2 amplification...

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Source

Identifiers

PMID: 28235629
DOI: 10.1016/j.humpath.2017.02.007

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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