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Article

Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases.

Biochimica et biophysica acta - 30 Mar 1999

Vestling M, Cedazo-Mínguez A, Adem A, Wiehager B, Racchi M, Lannfelt L, Cowburn R F

Abstract excerpt

Non-amyloidogenic alpha-secretase processing of amyloid precursor protein (APP) is stimulated by protein kinase C (PKC). Levels and activity of PKC are decreased in sporadic Alzheimer's disease skin fibroblasts. We investigated whether alterations in PKC and PKC-mediated APP processing occur also...

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Identifiers

PMID: 10101252
DOI: 10.1016/s0925-4439(99)00003-4

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10101252-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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