Article
Microtubule-associated protein tau in human fibroblasts with the Swedish Alzheimer mutation.
Neuroscience letters - 6 Dec 1996
Ingelson M, Vanmechelen E, Lannfelt L
Abstract excerpt
The principal neuropathological hallmarks of Alzheimer's disease (AD) are plaques containing amyloid beta peptide (Abeta) and tangles with hyperphosphorylated tau. Tau is predominantly found in the nervous system but has been reported in fibroblasts from individuals with and without AD. Abeta is also found outside the nervous system and is released three times more from cultured fibroblasts carrying the Swedish...
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