Article
The role of nucleotide binding and hydrolysis in the function of the fission yeast cdc18(+) gene product.
Genetics - 1 Apr 1999
DeRyckere D, Smith C L, Martin G S
Abstract excerpt
The fission yeast cdc18(+) gene is required for both initiation of DNA replication and the mitotic checkpoint that normally inhibits mitosis in the absence of DNA replication. The cdc18(+) gene product contains conserved Walker A and B box motifs. Studies of other ATPases have shown that these motifs are required for nucleotide binding and hydrolysis, respectively. We have observed that mutant strains in which...
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