Article
Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity.
Molecular and cellular biology - 1 Jul 1991
Ziman M, O'Brien J M, Ouellette L A, Church W R, Johnson D I
Abstract excerpt
The Saccharomyces cerevisiae CDC42 gene product, a member of the ras superfamily of low-molecular-weight GTP-binding proteins, is involved in the control of cell polarity. We have analyzed the effects of three CDC42 mutations (Gly to Val-12, Gln to Leu-61, and Asp to Ala-118) in the putative GTP-binding and hydrolysis domains and one mutation (Cys to Ser-188) in the putative isoprenylation site. The first three...
Topics
- Amino Acid Sequence
- Base Sequence
- Fungal Proteins
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Genes, Dominant
- Genes, Fungal
- Genes, Lethal
- Molecular Sequence Data
- Mutagenesis, Site-Directed