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Article

Polymerization of IgA and IgM: Roles of Cys309/Cys414 and the Secretory Tailpiece

1 Mar 1999

Abstract excerpt

We have investigated how the secretory tailpiece (tp), Cys414 and the amino acids flanking Cys414 or Cys309 are involved in regulating the different polymerization of IgM and IgA to pentamers and dimers/monomers, respectively. Whereas changing the tp of IgM to that of IgA has little effect on IgM polymerization, introducing the mu tp to IgA leads to the formation of larger than wild-type IgA polymers, including...

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Identifiers

PMID: 10092800
DOI: 10.4049/jimmunol.162.6.3448

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Source receipt: pubmed, retrieved 7 Sept 2026.

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