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Article

Understanding the biosynthesis of human IgM SAM-6 through a combinatorial expression of mutant subunits that affect product assembly and secretion.

PloS one - 1 Jan 2024

Hasegawa Haruki, Wang Songyu, Kast Eddie, Chou Hui-Ting, Kaur Mehma, Janlaor Tanakorn, Mostafavi Mina, Wang Yi-Ling, Li Peng

Abstract excerpt

Polymeric IgMs are secreted from plasma cells abundantly despite their structural complexity and intricate multimerization steps. To gain insights into IgM's assembly mechanics that underwrite such high-level secretion, we characterized the biosynthetic process of a natural human IgM, SAM-6, using a heterologous HEK293(6E) cell platform that allowed the production of IgMs both in hexameric and pentameric forms in...

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Identifiers

PMID: 38848420
DOI: 10.1371/journal.pone.0291568
PMCID: PMC11161108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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