Structural requirements for incorporation of J chain into human IgM and IgA

doi:10.1093/intimm/12.1.19

Article

Structural requirements for incorporation of J chain into human IgM and IgA

1 Jan 2000

Abstract excerpt

J chain is associated with pentameric IgM and dimeric IgA via disulfide bonds involving the penultimate cysteine residue in the secretory tailpiece of the mu or the alpha heavy chain. We have investigated the structural basis for incorporation of J chain by analyzing several IgM mutants, IgA mutants and IgG/IgM hybrid molecules. IgM mutants with the mu secretory tailpiece replaced by the alpha secretory tailpiece...

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