Article
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
Biochemical and biophysical research communications - 2 Apr 1999
Howlett C J, Bisson S A, Resek M E, Tigley A W, Robbins S M
Abstract excerpt
Hematopoietic cell kinase (Hck) is a member of the Src-family of protein tyrosine kinases. We have found that upon enzymatic activation of Hck by the heavy metal mercuric chloride, there was a rapid increase in the levels of tyrosine phosphorylation of several proteins including the proto-oncogene p120(Cbl). Fibroblasts that are transformed with an activated allele of Hck exhibit constitutive Cbl phosphorylation....
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