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Article

B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity.

Molecular cancer research : MCR - 1 Sept 2013

Nobumori Yumiko, Shouse Geoffrey P, Wu Yong, Lee Kyu Joon, Shen Binghui, Liu Xuan

Abstract excerpt

UNLABELLED: The hetero-trimeric PP2A serine/threonine phosphatases containing the regulatory subunit B56, and in particular B56γ, can function as tumor suppressors. In response to DNA damage, the B56γ subunit complexes with the PP2A AC core (B56γ-PP2A) and binds p53. This event promotes PP2A-mediated dephosphorylation of p53 at Thr55, which induces expression of p21, and the subsequent inhibition of cell...

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Identifiers

PMID: 23723076
DOI: 10.1158/1541-7786.MCR-12-0633
PMCID: PMC3778137

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