Chromosomal sensitivity to X-ray irradiation during the G2 phase in lymphocytes of patients with hereditary cutaneous malignant melanoma as compared to healthy controls.

doi:10.1016/s0027-5107(98)00245-0

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Article

Chromosomal sensitivity to X-ray irradiation during the G2 phase in lymphocytes of patients with hereditary cutaneous malignant melanoma as compared to healthy controls.

Mutation research - 10 Mar 1999

Andersson H C, Lewensohn R, Månsson-Brahme E

Abstract excerpt

Recent reports have suggested that elevated chromosomal aberration yields following X-ray irradiation of skin fibroblasts and peripheral lymphocytes in the G2 phase of the cell cycle are characteristic of affected members of cancer-prone families. These studies propose that the phenomenon is a consequence of impaired caffeine- and arabinofuranosylcytosine (ara-C)-sensitive DNA repair and might be a useful...

Topics

Adult
Aged
Case-Control Studies
Female
G2 Phase
Genetic Predisposition to Disease
Humans
Lymphocytes
Male
Melanoma
Middle Aged
Radiation Tolerance
Skin Neoplasms
X-Rays

Source

Open in PubMed

Identifiers

PMID: 10082912
DOI: 10.1016/s0027-5107(98)00245-0

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