Article
Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay.
Oncology reports - 1 Mar 2017
Baert Annelot, Depuydt Julie, Van Maerken Tom, Poppe Bruce, Malfait Fransiska, Van Damme Tim, De Nobele Sylvia, Perletti Gianpaolo, De Leeneer Kim, Claes Kathleen B M, Vral Anne
Abstract excerpt
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers). The aim of the present study was to use a G2 phase-specific micronucleus assay to investigate whether lymphocytes of healthy BRCA2 mutation carriers are characterized by increased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.