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Article

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

1 Dec 1997

Abstract excerpt

Members of the Smad family of proteins are thought to play important roles in transforming growth factor beta (TGF-beta)-mediated signal transduction. In response to TGF-beta, specific Smads become inducibly phosphorylated, form heteromers with Smad4, and undergo nuclear accumulation. In addition, overexpression of specific Smad combinations can mimic the transcriptional effect of TGF-beta on both the plasminogen...

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PMID: 9372933
DOI: 10.1128/mcb.17.12.7019

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Source receipt: pubmed, retrieved 7 Sept 2026.

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