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Article

Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.

The Journal of biological chemistry - 19 Oct 2001

Yuan W, Varga J

Abstract excerpt

Enhanced production of matrix metalloproteinase-1 (MMP-1, collagenase-1) is implicated in pathological tissue destruction. Transforming growth factor-beta (TGF-beta) prevents cytokine-induced MMP-1 gene expression in fibroblasts. In these studies, we examined the hypothesis that repression of MMP-1 may be mediated through the Smad signaling pathway. The results showed that Smad3 and Smad4, but not Smad1 or Smad2,...

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Identifiers

PMID: 11502752
DOI: 10.1074/jbc.M107081200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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