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Article

The role of local actin instability in axon formation.

Science (New York, N.Y.) - 19 Mar 1999

Bradke F, Dotti C G

Abstract excerpt

The role of localized instability of the actin network in specifying axonal fate was examined with the use of rat hippocampal neurons in culture. During normal neuronal development, actin dynamics and instability polarized to a single growth cone before axon formation. Consistently, global application of actin-depolymerizing drugs and of the Rho-signaling inactivator toxin B to nonpolarized cells produced neurons...

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Identifiers

PMID: 10082468
DOI: 10.1126/science.283.5409.1931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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