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Article

Susceptibility to Infectious Diseases:Leishmaniaas a Paradigm

1 Mar 1999

Abstract excerpt

The diverse response of individuals within populations to infectious pathogens remains poorly understood, although genetic determinants undoubtedly contribute in substantial ways to the outcome of infection. In a mouse model of infection with the intramacrophage protozoan Leishmania major, susceptibility correlates both with aberrant helper T cell differentiation biased towards the production of interleukin 4 and...

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PMID: 10081500
DOI: 10.1086/513843

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