Article
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.
Nature genetics - 1 Jun 2001
Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg A D, Patsch J R, Krempler F, Patsch W
Abstract excerpt
Obesity is the most common nutritional disorder in Western society. Uncoupling protein-2 (UCP2) is a recently identified member of the mitochondrial transporter superfamily that is expressed in many tissues, including adipose tissue. Like its close relatives UCP1 and UCP3, UCP2 uncouples proton entry in the mitochondrial matrix from ATP synthesis and is therefore a candidate gene for obesity. We show here that a...
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