Article
A Schizosaccharomyces pombe gene, ksg1, that shows structural homology to the human phosphoinositide-dependent protein kinase PDK1, is essential for growth, mating and sporulation.
Molecular & general genetics : MGG - 1 Feb 1999
Niederberger C, Schweingruber M E
Abstract excerpt
Fission yeast (Schizosaccharomyces pombe) requires inositol for growth, mating and sporulation. To define putative genes that are involved in the processing and transduction of the inositol signal, mutants that are temperature sensitive for growth and sporulation were selected on a medium containing non-limiting amounts of inositol. Two such mutants (ksg1-208 and ksg1-358) were analyzed, which are impaired in...
Topics
- 3-Phosphoinositide-Dependent Protein Kinases
- Amino Acid Sequence
- Cell Division
- Chromosome Mapping
- Cloning, Molecular
- DNA, Fungal
- Fungal Proteins
- Genes, Fungal
- Humans
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Protein Serine-Threonine Kinases