Article
Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Journal of basic microbiology - 1 Jan 2003
Gräub Remo, Hilti Norma, Niederberger Christian, Schweingruber M Ernst
Abstract excerpt
It has previously been shown that the Schizosaccharomyces pombe mutant ksg1-358 has a mating and sporulation defect at 30 degrees C and that it is temperature sensitive for growth at 35 degrees C. However the molecular basis for these phenotypes remained largely unknown. In this study we show that ksg1-358 mutant cells lysed at the non-permissive temperature, which could be prevented by sorbitol. Overexpression...
Topics
- Cell Wall
- Genes, Fungal
- Genetic Complementation Test
- Glucan Endo-1,3-beta-D-Glucosidase
- Inositol
- Multienzyme Complexes
- Mutation
- Peptide Hydrolases
- Protein Binding
- Protein Kinases