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Article

C-terminal deletion mutant of MRE-binding transcription factor-1 inhibits MRE-driven gene expression.

Journal of cellular biochemistry - 15 Oct 2004

Kimura Tomoki, Itoh Norio, Sone Tomomichi, Tanaka Keiichi, Isobe Masakazu

Abstract excerpt

Heavy metal-induced transcriptional activation of the genes coding for metallothionein (MT) is mediated by a cis-acting DNA element, the metal-responsive element (MRE). MRE-binding transcription factor-1 (MTF-1) is a highly conserved heavy metal-induced transcriptional activator. MTF-1 also activates transcription in response to oxidative stress and regulates the expression of several cytoprotective factor genes,...

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PMID: 15378601
DOI: 10.1002/jcb.20210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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