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Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action.

Environmental and molecular mutagenesis - 1 Jan 2000

Baird William M, Hooven Louisa A, Mahadevan Brinda

Abstract excerpt

Polycyclic aromatic hydrocarbons (PAHs) are a class of widespread environmental carcinogens. Most of our knowledge of their mechanisms of metabolic activation to DNA-binding "ultimate carcinogenic" metabolites has come from analysis of the DNA interaction products formed by these highly reactive intermediates. Studies of their role in forming DNA-binding intermediates identical to those formed in vivo from the...

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Identifiers

PMID: 15688365
DOI: 10.1002/em.20095

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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