Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription.

EMBO reports - 1 Apr 2001

Saller E, Bienz M

Abstract excerpt

Brinker is a nuclear protein that antagonizes Dpp signalling in Drosophila. Its expression is negatively regulated by Dpp. Here, we show that Brinker represses Ultrabithorax (Ubx) in the embryonic midgut, a HOX gene that activates, and responds to, the localized expression of Dpp during endoderm induction. We find that the functional target for Brinker repression coincides with the Dpp response sequence in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography
Share to Drosophila
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Glutathione Transferase

Share to Homeodomain Proteins

Share to Insect Proteins

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 11306550
DOI: 10.1093/embo-reports/kve068
PMCID: PMC1083865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription.PMID 11306550Read ↗

The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation.Semantic proximity Read ↗

brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.Semantic proximity Read ↗

Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker.Semantic proximity Read ↗

Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker.Semantic proximity Read ↗

The role of brinker in mediating the graded response to Dpp in early Drosophila embryos.Semantic proximity Read ↗

A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.Semantic proximity Read ↗

Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization.Semantic proximity Read ↗

Manipulating the sensitivity of signal-induced repression: quantification and consequences of altered brinker gradients.Semantic proximity Read ↗

Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis.Semantic proximity Read ↗

The role of brinker in eggshell patterning.Semantic proximity Read ↗

Dpp-responsive silencers are bound by a trimeric Mad-Medea complex.Semantic proximity Read ↗

Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.