Article
Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 1990
Boswell M V, Morgan P G, Sedensky M M
Abstract excerpt
The authors tested whether mutant strains of Caenorhabditis elegans with altered sensitivity to volatile anesthetics have altered responses to GABA or GABA-agonists. They determined the ED50s of the wild-type strain N2 and two mutant strains of C. elegans to a GABA-mimetic ivermectin (IVM) and to...
Topics
- Animals
- Caenorhabditis
- Dose-Response Relationship, Drug
- Drug Resistance
- Enflurane
- GABA Antagonists
- Halothane
- Ivermectin
- Motor Activity
- Mutation
- gamma-Aminobutyric Acid