Article
Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 1990
Boswell M V, Morgan P G, Sedensky M M
Abstract excerpt
The authors tested whether mutant strains of Caenorhabditis elegans with altered sensitivity to volatile anesthetics have altered responses to GABA or GABA-agonists. They determined the ED50s of the wild-type strain N2 and two mutant strains of C. elegans to a GABA-mimetic ivermectin (IVM) and to GABA. unc-79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA. unc-9, a...
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