Article
Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 1999
Sutherland M L, Williams S H, Abedi R, Overbeek P A, Pfaffinger P J, Noebels J L
Abstract excerpt
The nervous system maintains a delicate balance between excitation and inhibition, partly through the complex interplay between voltage-gated sodium and potassium ion channels. Because K+ channel blockade or gene deletion causes hyperexcitability, it is generally assumed that increases in K+ channel gene expression should reduce neuronal network excitability. We have tested this hypothesis by creating a...
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