Article
Targeted attenuation of electrical activity in Drosophila using a genetically modified K(+) channel.
Neuron - 13 Sept 2001
White B H, Osterwalder T P, Yoon K S, Joiner W J, Whim M D, Kaczmarek L K, Keshishian H
Abstract excerpt
We describe here a general technique for the graded inhibition of cellular excitability in vivo. Inhibition is accomplished by expressing a genetically modified Shaker K(+) channel (termed the EKO channel) in targeted cells. Unlike native K(+) channels, the EKO channel strongly shunts depolarizing current: activating at potentials near E(K) and not inactivating. Selective targeting of the channel to neurons,...
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