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Article

Dissection of synaptic excitability phenotypes by using a dominant-negative Shaker K+ channel subunit.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2005

Mosca Timothy J, Carrillo Robert A, White Benjamin H, Keshishian Haig

Abstract excerpt

During nervous system development, synapses undergo morphological change as a function of electrical activity. In Drosophila, enhanced activity results in the expansion of larval neuromuscular junctions. We have examined whether these structural changes involve the pre- or postsynaptic partner by selectively enhancing electrical excitability with a Shaker dominant-negative (SDN) potassium channel subunit. We find...

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Identifiers

PMID: 15728380
DOI: 10.1073/pnas.0406164102
PMCID: PMC552910

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