Abbreviated action potential kinetics in a mouse model of potassium channel overexpression during hippocampal development.

Abstract excerpt

Loss or "gain" of function mutations in voltage-gated ion channels often results in an adverse neurological phenotype. We have examined the electrical characteristics of hippocampal pyramidal cells in a transgenic mouse model to determine how overexpression of a Shaker-type potassium channel subunit during early postnatal development might alter excitability properties of developing neurons. We found that in CA3...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Action Potentials
• Share to Electric Stimulation