Article
Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis.
Genetics - 1 Mar 1999
Yue L, Karr T L, Nathan D F, Swift H, Srinivasan S, Lindquist S
Abstract excerpt
The Hsp90 chaperone protein maintains the activities of a remarkable variety of signal transducers, but its most critical functions in the context of the whole organism are unknown. Point mutations of Hsp83 (the Drosophila Hsp90 gene) obtained in two different screens are lethal as homozygotes. We report that eight transheterozygous mutant combinations produce viable adults. All exhibit the same developmental...
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