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Article

Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.

Antimicrobial agents and chemotherapy - 1 Mar 1999

McMurry L M, McDermott P F, Levy S B

Abstract excerpt

Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type inhA gene on a multicopy plasmid. Replacement of the mutant chromosomal inhA genes with wild-type inhA...

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Identifiers

PMID: 10049298
DOI: 10.1128/AAC.43.3.711
PMCID: PMC89191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.PMID 10049298Read ↗

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Semantic proximity Read ↗

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Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.Semantic proximity Read ↗

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.Semantic proximity Read ↗

NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.Semantic proximity Read ↗

Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues.Semantic proximity Read ↗

Biochemical and genetic data suggest that InhA is not the primary target for activated isoniazid in Mycobacterium tuberculosis.Semantic proximity Read ↗

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Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.Semantic proximity Read ↗

Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.Semantic proximity Read ↗

A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus.Semantic proximity Read ↗

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