A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus.

doi:10.1016/j.ijantimicag.2012.04.021

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Article

A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus.

International journal of antimicrobial agents - 1 Sept 2012

Ciusa Maria Laura, Furi Leonardo, Knight Daniel, Decorosi Francesca, Fondi Marco, Raggi Carla, Coelho Joana Rosado, Aragones Luis, Moce Laura, Visa Pilar, Freitas Ana Teresa, Baldassarri Lucilla, Fani Renato, Viti Carlo, Orefici Graziella, Martinez Jose Luis, Morrissey Ian, Oggioni Marco Rinaldo

Abstract excerpt

The widely used biocide triclosan selectively targets FabI, the NADH-dependent trans-2-enoyl-acyl carrier protein reductase, which is an important target for narrow-spectrum antimicrobial drug development. In relation to the growing concern about biocide resistance, we compared in vitro mutants and clinical isolates of Staphylococcus aureus with reduced triclosan susceptibility. Clinical isolates of S. aureus as...

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PMID: 22789727
DOI: 10.1016/j.ijantimicag.2012.04.021

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