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Article

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.

Biochemistry - 4 Jul 2000

Parikh S L, Xiao G, Tonge P J

Abstract excerpt

Structural and genetic studies indicate that the antibacterial compound triclosan, an additive in many personal care products, is an inhibitor of EnvM, the enoyl reductase from Escherichia coli. Here we show that triclosan specifically inhibits InhA, the enoyl reductase from Mycobacterium tubercu...

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Identifiers

PMID: 10869170
DOI: 10.1021/bi0008940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10869170-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.PMID 10869170Read ↗

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.Semantic proximity Read ↗

Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.Semantic proximity Read ↗

Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.Semantic proximity Read ↗

Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.Semantic proximity Read ↗

Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.Semantic proximity Read ↗

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.Semantic proximity Read ↗

Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues.Semantic proximity Read ↗

Mutation in Eth A protein of Mycobacterium tuberculosis conferred drug tolerance against enthinoamide in Mycobacterium smegmatis mc2155.Semantic proximity Read ↗

Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.Semantic proximity Read ↗

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Semantic proximity Read ↗

Mechanisms for isoniazid action and resistance.Semantic proximity Read ↗

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis.Semantic proximity Read ↗

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