Article
Balanced biosynthesis of major membrane components through regulated degradation of the committed enzyme of lipid A biosynthesis by the AAA protease FtsH (HflB) in Escherichia coli.
Molecular microbiology - 1 Feb 1999
Ogura T, Inoue K, Tatsuta T, Suzaki T, Karata K, Young K, Su L H, Fierke C A, Jackman J E, Raetz C R, Coleman J, Tomoyasu T, Matsuzawa H
Abstract excerpt
The suppressor mutation, named sfhC21, that allows Escherichia coli ftsH null mutant cells to survive was found to be an allele of fabZ encoding R-3-hydroxyacyl-ACP dehydrase, involved in a key step of fatty acid biosynthesis, and appears to upregulate the dehydrase. The ftsH1(Ts) mutation increased the amount of lipopolysaccharide at 42 degrees C. This was accompanied by a dramatic increase in the amount of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.