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Article

Conditional lethality and suppressor analysis of plasmid-based temperature-sensitive fabZ expression in Pseudomonas aeruginosa.

The Journal of biological chemistry - 1 Jun 2025

Chen Zhenhua, Lu Junpeng, Tang Qinghai, Yang Zhili

Abstract excerpt

FabZ, a β-hydroxyacyl-acyl carrier protein dehydratase in the type II fatty acid synthesis pathway, is essential for the viability of Pseudomonas aeruginosa by ensuring proper fatty acid elongation and membrane stability. However, the precise genetic interactions between fabZ and lipid A biosynthesis genes, such as lpxA and lpxC, as well as the potential existence of other suppressor genes of fabZ in P....

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PMID: 40294648
DOI: 10.1016/j.jbc.2025.108553
PMCID: PMC12152623

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Conditional lethality and suppressor analysis of plasmid-based temperature-sensitive fabZ expression in Pseudomonas aeruginosa.PMID 40294648Read ↗

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