Article
Enhanced apoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells.
The Journal of biological chemistry - 18 May 2007
Nagao Kohjiro, Takahashi Kei, Hanada Kentaro, Kioka Noriyuki, Matsuo Michinori, Ueda Kazumitsu
Abstract excerpt
ATP binding cassette protein A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. It is proposed that ABCA1 reorganizes the plasma membrane and generates more loosely packed domains that facilitate apoA-I-dependent cholesterol efflux. In this study, we examined the effects of the cellular sphingomyelin level on HDL formation by ABCA1 by using a Chinese hamster...
Topics
- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Transporters
- Animals
- Apolipoprotein A-I
- Biological Transport, Active
- CHO Cells
- Cell Membrane
- Cholesterol
- Cricetinae
- Cricetulus