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Article

Caffeine can override the S-M checkpoint in fission yeast.

Journal of cell science - 1 Mar 1999

Wang S W, Norbury C, Harris A L, Toda T

Abstract excerpt

The replication checkpoint (or 'S-M checkpoint') control prevents progression into mitosis when DNA replication is incomplete. Caffeine has been known for some time to have the capacity to override the S-M checkpoint in animal cells. We show here that caffeine also disrupts the S-M checkpoint in the fission yeast Schizosaccharomyces pombe. By contrast, no comparable effects of caffeine on the S. pombe DNA damage...

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Identifiers

PMID: 10036242
DOI: 10.1242/jcs.112.6.927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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