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Article

The novel murine calmodulin-binding protein Sha1 disrupts mitotic spindle and replication checkpoint functions in fission yeast.

Journal of cell science - 18 Dec 1998

Craig R, Norbury C

Abstract excerpt

Entry into mitosis is normally blocked in eukaryotic cells that have not completed replicative DNA synthesis; this 'S-M' checkpoint control is fundamental to the maintenance of genomic integrity. Mutants of the fission yeast Schizosaccharomyces pombe defective in the S-M checkpoint fail to arrest the cell cycle when DNA replication is inhibited and hence attempt mitosis and cell division with unreplicated...

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Identifiers

PMID: 9819352
DOI: 10.1242/jcs.111.24.3609

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Research trail→

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The novel murine calmodulin-binding protein Sha1 disrupts mitotic spindle and replication checkpoint functions in fission yeast.PMID 9819352Read ↗

Calmodulin localizes to the spindle pole body of Schizosaccharomyces pombe and performs an essential function in chromosome segregation.Semantic proximity Read ↗

Caffeine can override the S-M checkpoint in fission yeast.Semantic proximity Read ↗

Fission yeast Sap1 protein is essential for chromosome stability.Semantic proximity Read ↗

Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.Semantic proximity Read ↗

Sum1, a highly conserved WD-repeat protein, suppresses S-M checkpoint mutants and inhibits the osmotic stress cell cycle response in fission yeast.Semantic proximity Read ↗

Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression.Semantic proximity Read ↗

Mitotic abnormalities and spindle assembly checkpoint inactivation in a cell model of Shwachman-Diamond syndrome with mutations in the Shwachman-Bodian-Diamond syndrome gene, 258+2T > C.Semantic proximity Read ↗

A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.Semantic proximity Read ↗

CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast.Semantic proximity Read ↗

Schizosaccharomyces pombe histone acetyltransferase Mst1 (KAT5) is an essential protein required for damage response and chromosome segregation.Semantic proximity Read ↗

Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.Semantic proximity Read ↗

Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe.Semantic proximity Read ↗

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