Article
The novel murine calmodulin-binding protein Sha1 disrupts mitotic spindle and replication checkpoint functions in fission yeast.
Journal of cell science - 18 Dec 1998
Craig R, Norbury C
Abstract excerpt
Entry into mitosis is normally blocked in eukaryotic cells that have not completed replicative DNA synthesis; this 'S-M' checkpoint control is fundamental to the maintenance of genomic integrity. Mutants of the fission yeast Schizosaccharomyces pombe defective in the S-M checkpoint fail to arrest...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Calmodulin
- Calmodulin-Binding Proteins
- Cell Division
- Cell Nucleus
- Cytoplasm
- DNA, Complementary
- Drosophila Proteins
- Gene Expression Regulation
- Mice
- Microtubule-Associated Proteins
- Mitosis
- Molecular Sequence Data
- Nerve Tissue Proteins
- Phenotype
- S Phase