Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cisplatin sensitivity correlates with its ability to cause cell cycle arrest via a wee1 kinase-dependent pathway in Schizosaccharomyces pombe.

Journal of cellular physiology - 1 Jun 1994

Thiebaut F, Enns R, Howell S B

Abstract excerpt

Mutants of Schizosaccharomyces pombe were used to define genes involved in the cell cycle arrest produced by cisplatin (DDP), an agent that causes both DNA damage and inhibition of DNA synthesis. Previous work has demonstrated that strains with defective or absent wee1+ function fail to arrest in G2 when DNA is damaged, but do arrest when DNA synthesis is inhibited (Rowley et al., 1992a, Nature, 356:353-355)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Proteins
Share to DNA, Fungal
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Kinetics

Share to Models, Biological

Share to Species Specificity

Share to Time Factors

Source

Identifiers

PMID: 8188765
DOI: 10.1002/jcp.1041590315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cisplatin sensitivity correlates with its ability to cause cell cycle arrest via a wee1 kinase-dependent pathway in Schizosaccharomyces pombe.PMID 8188765Read ↗

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.Semantic proximity Read ↗

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.Semantic proximity Read ↗

A mammalian-like DNA damage response of fission yeast to nucleoside analogs.Semantic proximity Read ↗

Abrogation of the G2 Checkpoint by Inhibition of Wee-1 Kinase Results in Sensitization of p53-Deficient Tumor Cells to DNA-Damaging AgentsSemantic proximity Read ↗

Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.Semantic proximity Read ↗

A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.Semantic proximity Read ↗

DNA repair functions that control sensitivity to topoisomerase-targeting drugs.Semantic proximity Read ↗

Caffeine can override the S-M checkpoint in fission yeast.Semantic proximity Read ↗

DNA damage and cell cycle control in Schizosaccharomyces pombe.Semantic proximity Read ↗

Novel alleles of cdc13 and cdc2 isolated as suppressors of mitotic catastrophe in Schizosaccharomyces pombe.Semantic proximity Read ↗

Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine.Semantic proximity Read ↗

Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.