Article
Cisplatin sensitivity correlates with its ability to cause cell cycle arrest via a wee1 kinase-dependent pathway in Schizosaccharomyces pombe.
Journal of cellular physiology - 1 Jun 1994
Thiebaut F, Enns R, Howell S B
Abstract excerpt
Mutants of Schizosaccharomyces pombe were used to define genes involved in the cell cycle arrest produced by cisplatin (DDP), an agent that causes both DNA damage and inhibition of DNA synthesis. Previous work has demonstrated that strains with defective or absent wee1+ function fail to arrest in...
Topics
- Cell Cycle
- Cell Cycle Proteins
- Cisplatin
- DNA, Fungal
- Dose-Response Relationship, Drug
- Flow Cytometry
- Genes, Fungal
- Genotype
- Kinetics
- Models, Biological
- Nuclear Proteins
- Protein Kinases
- Protein-Tyrosine Kinases
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Species Specificity
- Time Factors