Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles.

doi:10.1111/j.1399-0039.2006.00678.x

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Article

Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles.

Tissue antigens - 1 Oct 2006

Haydardedeoğlu F E, Tutkak H, Köse K, Düzgün N

Abstract excerpt

Acute rheumatic fever (ARF) is a systemic inflammatory disease that develops as a consequence of an exaggerated immune response to group A beta-haemolytic streptococci, which causes pharyngitis. Major manifestations of ARF include carditis, arthritis and chorea. Several investigators have attempted to establish a relation between ARF and human leucocyte antigens (HLA). Heterogeneity in various studies has been...

Topics

Adult
Alleles
Female
Gene Frequency
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Male
Middle Aged
Pharyngitis
Rheumatic Heart Disease
Streptococcal Infections

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Open in PubMed

Identifiers

PMID: 17026463
DOI: 10.1111/j.1399-0039.2006.00678.x

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