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Article

Genetic mutations associated with cigarette smoking in pancreatic cancer.

Cancer research - 15 Apr 2009

Blackford Amanda, Parmigiani Giovanni, Kensler Thomas W, Wolfgang Christopher, Jones Siân, Zhang Xiaosong, Parsons D Willams, Lin Jimmy Cheng-Ho, Leary Rebecca J, Eshleman James R, Goggins Michael, Jaffee Elizabeth M, Iacobuzio-Donahue Christine A, Maitra Anirban, Klein Alison, Cameron John L, Olino Kelly, Schulick Richard, Winter Jordan, Vogelstein Bert, Velculescu Victor E, Kinzler Kenneth W, Hruban Ralph H

Abstract excerpt

Cigarette smoking doubles the risk of pancreatic cancer, and smoking accounts for 20% to 25% of pancreatic cancers. The recent sequencing of the pancreatic cancer genome provides an unprecedented opportunity to identify mutational patterns associated with smoking. We previously sequenced >750 mil...

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Source

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Identifiers

PMID: 19351817
DOI: 10.1158/0008-5472.CAN-09-0015
PMCID: PMC2669837

Genes

KRAS
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19351817-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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