Article
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Environmental and molecular mutagenesis - 1 Jun 2009
Crous-Bou Marta, Porta Miquel, López Tomàs, Jariod Manel, Malats Núria, Morales Eva, Guarner Luisa, Rifà Juli, Carrato Alfredo, Real Francisco X
Abstract excerpt
BACKGROUND: In pancreatic ductal adenocarcinoma (PDA), evidence on the etiopathogenic role of alcohol consumption in the occurrence of K-ras mutations is scant, and the role of alcohol in pancreatic carcinogenesis is not well established. We analyzed the relation between lifetime consumption of alcohol and mutations in codon 12 of the K-ras oncogene in patients with PDA. METHODS: Incident cases of PDA were...
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