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Article

The ACE deletion polymorphism is not associated with Parkinson's disease.

European neurology - 1 Jan 1999

Mellick G D, Buchanan D D, McCann S J, Davis D R, Le Couteur D G, Chan D, Johnson A G

Abstract excerpt

The deletion allele (D allele) polymorphism in the angiotensin converting enzyme (ACE) gene is associated with increased levels of the neuropeptide substance P in the basal ganglia and substantia nigra. A reduction of substance P levels in the brain occurs in Parkinson's disease (PD) and has been implicated in the pathogenesis of the disease. We investigated the hypothesis that the D allele may be protective...

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Source

Identifiers

PMID: 10023114
DOI: 10.1159/000008012

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ACE deletion polymorphism is not associated with Parkinson's disease.PMID 10023114Read ↗

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