Article
The EcoRV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease.
Neuroscience letters - 7 Jan 2000
Costa-Mallen P, Checkoway H, Fishel M, Cohen A W, Smith-Weller T, Franklin G M, Swanson P D, Costa L G
Abstract excerpt
We previously observed an association with Parkinson's (PD), and modification of the effect of smoking on PD, by a polymorphism of the monoamine oxidase B (MAO-B) gene. The A form of monoamine oxidase (MAO-A) shares with MAO-B many characteristics that could be relevant to PD, especially proneuroxicant bioactivation and dopamine metabolism. MAO-A is also inhibited by tobacco smoke, which bears an apparent...
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