Article
No allelic association between Parkinson's disease and dopamine D2, D3, and D4 receptor gene polymorphisms.
American journal of medical genetics - 15 Dec 1994
Nanko S, Ueki A, Hattori M, Dai X Y, Sasaki T, Fukuda R, Ikeda K, Kazamatsuri H
Abstract excerpt
Parkinson's disease is thought to be caused by a combination of unknown environmental, genetic, and degenerative factors. Evidence from necropsy brain samples and pharmacokinetics suggests involvement of dopamine receptors in the pathogenesis or pathophysiology of Parkinson's disease. Genetic ass...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 2
- Female
- Genetic Markers
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Polymorphism, Genetic
- Receptors, Dopamine
- Receptors, Dopamine D2
- Receptors, Dopamine D3