Article
Genetic polymorphism of Angiotensin-Converting Enzyme is not associated with the development of Parkinson's disease and of L-dopa-induced adverse effects.
Journal of the neurological sciences - 15 Jan 2009
Pascale Esterina, Purcaro Carlo, Passarelli Emanuela, Guglielmi Renzo, Vestri Anna Rita, Passarelli Francesca, Meco Giuseppe
Abstract excerpt
Sporadic Parkinson's disease (PD) is a frequent neurodegenerative movement disorder. Both environmental and genetic factors have been studied in the etiology of PD. Among genetic factors, increasing evidences suggest that deletion/insertion (D/I) gene polymorphism of the angiotensin I-converting enzyme (ACE) may be involved in the pathogenesis of PD and in the occurrence of the adverse effects of chronic L-dopa...
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